Genomic Characterization of Canis Familiaris Papillomavirus Type 25, a Novel Papillomavirus Associated with a Viral Plaque from the Pinna of a Dog

A 14-year-old West Highland White terrier dog developed multiple raised plaques that were confined to the concave surface of right pinna. Histology allowed a diagnosis viral plaque, although lesions contained some unusual microscopic features. papillomaviral (PV) DNA sequence was amplified from plaque using consensus PCR primers. The used as template design ‘outward facing’ primers, which amplification complete PV sequence. 7778 bp and predicted code for five early genes two late genes. ORF L1 showed highest (83.9%) similarity CPV15, phylogenetic analysis revealed novel clustered with species 3 ChiPVs. designated canine papillomavirus (CPV) type 25. As CPV25 not previously detected in this may be rare cause skin disease dogs. However, remain pinna reported dogs, it is possible could more common area skin. findings case expand number types Evidence suggests that, compared other ChiPV types, infection by results atypical locations histological